Circprot Publications

CIRCPROT papers mentioning JPND funding (Status: February 2021) 

(Chronologically descending) 


Migazzi1 A., Scaramuzzino, C., Anderson E., Tripathy D., Hernández I.H., Virlogeux A., Zuccato C., Caricasole A., Ratovitski T., Ross C.A., Pandey U., Lucas J.J, Saudou F., Pennuto M., Basso M. (2021) Huntingtin-mediated axonal transport requires arginine methylation by PRMT6 Cell reports in Press

Casarotto P.C., Girych M., Fred S.M., Kovaleva, V., Moliner R., Enkavi G., Biojone C., Cannarozzo C., Sahu, M.P., Kaurinkoski, K., Brunello C.A., Steinzeig A., Winkel F., Patil S., Vestring S., Serchov T., Diniz C.R.A.F., Laukkanen L., Cardon I., Antila H., Rog T., Piepponen, T.P., Bramham C.R., Normann C., Lauri S.E., Saarma M., Vattulainen I., Castrén E.  (2021)  Antidepressant drugs act by directly binding to TRKB neurotrophin receptors. Cell 184, 1299-1313,

Garad M, Edelmann E, Leßmann V. (2021) Impairment of Spike-Timing-Dependent Plasticity at Schaffer Collateral-CA1 Synapses in Adult APP/PS1 Mice Depends on Proximity of Aβ Plaques. Int J Mol Sci. 22(3):1378.

Lesnikova A., Casarotto P.C.,  Fred S.M.,  Voipio M, Winkel F.,  Steinzeig A.,  Antila H.,  Umemori J.,  Biojone C.,  and Castrén E.  Chondroitinase and antidepressants promote plasticity by releasing TRKB from dephosphorylating control of PTPσ in parvalbumin neurons. (2021) J. Neurosci. 41(5):972-980.


de Sousa Maciel I.,  Sales A.J.,  Casarotto P.C.,  Castrén E.,  Biojone C.,  Samia R. L. Joca S.R.L. Nitric Oxide Synthase inhibition counteracts the stress-induced DNA methyltransferase 3b expression in the hippocampus of rats.  (2020) Eur. J. Neurosci.  Nov 10. doi: 10.1111/ejn.15042.

Kartalou GI, Salgueiro-Pereira AR, Endres T, Lesnikova A, Casarotto P, Pousinha P, Delanoe K, Edelmann E, Castrén E, Gottmann K, Marie H, Lessmann V (2020) Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model. Int J Mol Sci, 21, 8957.  

Brigadski T, Lessmann V (2020) The physiology of regulated BDNF release. Cell Tissue Res. 382(1):15-45. doi: 10.1007/s00441-020-03253-2.

Meis S, Endres T, Lessmann V (2020) Neurotrophin signalling in amygdala-dependent cued fear learning. Cell Tissue Res. 382(1):161-172. doi: 10.1007/s00441-020-03260-3.

Kartalou GI, Endres T, Lessmann V*, Gottmann K* (2020) Golgi-Cox impregnation combined with fluorescence staining of amyloid plaques reveals local spine loss in an Alzheimer mouse model. J Neurosci Methods 341:108797. doi:10.1016/j.jneumeth.2020.108797

Ehinger Y, Bruyère J, Panayotis N, Abada Y-S, Saidi L, Matagne V, Scaramuzzino C, Vitet H, Delatour B, Villard L, Saudou F, Roux J-C. (2020) Huntington phosphorylation governs BDNF homeostasis and improves the phenotype of Mecp2 ko mice. EMBO Mol Med 12(2):e10889


Fred S.M., Laukkanen L., Vesa L., Goos H., Cardon I., Moliner R., Maritzen T., Varjosalo M., Casarotto P.C., Castrén E. (2019) Pharmacologically diverse antidepressant drugs disrupt the interaction of BDNF receptor TRKB and the endocytic adaptor AP-2. J Biol Chem 294(48):18150-18161

Vezzoli E, Caron I, Talpo F, Besusso D, Conforti P, Battaglia E, Sogne E, Falqui A, Petricca L, Verani M, Martufi P, Caricasole A, Bresciani A, Cecchetti O, Rivetti di Val Cervo P, Sancini G, Riess O, Nguyen H, Seipold L, Saftig P, Biella G, Cattaneo E, Zuccato C. (2019)  Inhibiting pathologically active ADAM10 rescues synaptic and cognitive decline in Huntington´s disease.  J Clin Invest. 130:2390-2403. 

Pousinha PA, Mouska X, Bianchi D, Temido-Ferreira M, Rajão-Saraiva J, Gomes R, Fernandez SP, Salgueiro-Pereira AR, Gandin C, Raymond EF, Barik J, Goutagny R, Bethus I, Lopes LV, Migliore M, Marie H. (2019) The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.  Cell Reports 29(2):317-331.e5. 

Meis S, Endres T, Munsch T, Lessmann V. (2019) Impact of Chronic BDNF Depletion on GABAergic Synaptic Transmission in the Lateral Amygdala. Int J Mol Sci. 20(17). doi: 10.3390/ijms20174310. 

Solinas S, Edelmann E, Lessmann V, Migliore M. (2019) A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Computational Biology 15(4):e1006975.

Lima-Ojeda J.M., Castrén E. (2019) BDNF and VEGF: Siamese twins in the antidepressant action. Biol. Psychiatry 86: 81-83.

Steinzeig A., Cannarozzo C., Castrén E. Fluoxetine-induced plasticity in the visual cortex outlasts the duration of the naturally occurring critical period. (2019) Eur J. Neurosci. 50: 3663-3673, doi: 10.1111/ejn.14512.

Fonseca-Gomes, J., Jerónimo-Santos, A., Lesnikova, A., Casarotto, P., Castrén, E., Sebastião, A. M., and Diógenes, M. J. (2019). Trkb-icd fragment, originating from bdnf receptor cleavage, is translocated to cell nucleus and phosphorylates nuclear and axonal proteins. Frontiers in Mol Neurosci 12:4. doi: 10.3389/fnmol.2019.00004. 


Moutaux E, Christaller W, Scaramuzzino C, Genoux A, Charlot B, Cazorla M, Saudou F. (2018). Neuronal network matu¬ra¬tion differently affects secretory vesicles and mitochondria transport in axons. Scientific Reports. Sep 7;8(1):13429.

Michels B, Zwaka H, Bartels R, Lushchak O, Franke K, Endres T, Fendt M, Song I, Bakr M, Budragchaa T, Westermann B, Mishra D, Eschbach C, Schreyer S, Lingnau A, Vahl C, Hilker M, Menzel R, Kahne T, Lessmann V, Dityatev A, Wessjohann L, Gerber B. (2018) Memory enhancement by ferulic acid ester across species. Science Advances 4: eaat6994.

Virlogeux A, Moutaux E, Christaller W, Genoux A, Bruyère J, Fino E, Charlot B, Cazorla M, Saudou F. (2018): Reconstituting Corticostriatal Network On-a-Chip Reveals the Contribution of the Presynaptic Compartment to Huntington´s Disease. Cell Reports, Jan 2;22(1):110-122.

Umemori, J., Winkel, F., Didio, G., Llach Pou, M., Castren, E. (2018). Iplasticity: Induced juvenile-like plasticity in the adult brain as a mechanism of antidepressants. Psychiatry Clin Neurosci 72, 633-653.



Nair RR, Patil S, Tiron A, Kanhema T, Panja D, Schiro L, Parobzak K, Wilczynski G, Bramham CR. (2017) Dynamic Arc SUMOylation and selective interaction with F-actin binding protein drebrin A in LTP consolidation in vivo. Front Synaptic Neurosci. doi:10.3389/fnsyn.2017.00008.